Reaktion #56374

Reaktionsgleichung

α-cyano-4-fluoro-3-phenoxybenzyl methanesulfonate

3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid

potassium bicarbonate

→

α-cyano-4-fluoro-3-phenoxybenzyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate

Lösungsmittel

THF DMF

THF DMF

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water (3×) and sat. NaCl
2. 2
   Sonstigedried
3. 3
   Sonstigesolvent is removed
4. 4
   SonstigeThe crude product is purified by prep

Vorschrift

3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid (0.82 g, 3.40 mmol) is stirred together with 0.34 g (3.40 mmol) potassium bicarbonate in 10 ml THF/DMF (1:1) for 15 minutes. Then 1.0 g (3.40 mmol) α-cyano-4-fluoro-3-phenoxybenzyl methanesulfonate in 5 ml THF/DMF (1:1) is added and the mixture stirred for approximately 48 hours. The reaction is diluted with ether, washed with water (3×) and sat. NaCl, dried and solvent is removed. The crude product is purified by prep. TLC developing with 10% ethyl acetate/hexane to yield α-cyano-4-fluoro-3-phenoxybenzyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate.

Quelle