Reaktion #56323

Reaktionsgleichung

2-Methoxyaniline

sodium carbonate

2-Bromomethyl-4-methyl-1,3-dioxolane

→

N-(4-methyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a mechanical stirrer
2. 2
   Temperaturthermometer and reflux condenser
3. 3
   FiltrationAfter this time the reaction mixture was filtered
4. 4
   workup.ADDITIONadditional sodium carbonate (5.0 grams) was added to the filtrate
5. 5
   workup.DISTILLATIONvacuum distilled
6. 6
   Sonstigethe fraction boiling at 120° C. and 0.07 mm of Hg pressure was collected

Vorschrift

2-Methoxyaniline (99 grams; 0.6 moles) and sodium carbonate (31.6 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4-methyl-1,3-dioxolane (25 ml) was added and the reaction mixture was heated at a temperature of about 100° C. for a period of about 4 hours. After this time the reaction mixture was filtered and additional sodium carbonate (5.0 grams) was added to the filtrate. The mixture was then vacuum distilled and the fraction boiling at 120° C. and 0.07 mm of Hg pressure was collected to yield the desired product N-(4-methyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline.

Quelle