Reaktion #56282

Reaktionsgleichung

3-chlorosulfonylthiophene-2-carboxylic acid chloride

methanol

hydrogen chloride

→

3-chlorosulfonylthiophene-2-carboxylic acid methyl ester

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated
2. 2
   SonstigeThe mixture is evaporated to dryness in vacuo
3. 3
   Sonstigeto crystallize

Vorschrift

48 G. (0.196 mol) of the obtained 3-chlorosulfonylthiophene-2-carboxylic acid chloride are dissolved in 500 ml. of absolute chloroform, 9.6 g. (0.3 mol) of absolute methanol are added and the mixture is heated to reflux for 3 hours [until no more hydrogen chloride evolution]. The mixture is evaporated to dryness in vacuo and the residue allowed to crystallize. There is obtained pure 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.

Quelle