Reaktion #56278

Reaktionsgleichung

3-sulfothiophene-2-carboxylic acid methyl ester

thionyl chloride

→

3-chlorosulfonylthiophene-2-carboxylic acid methyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 16 hours
2. 2
   SonstigeThe mixture is then evaporated to dryness in vacuo
3. 3
   Sonstigethe remaining bright-yellow oil is brought to crystallization with petroleum ether

Vorschrift

7.4 G. of crude 3-sulfothiophene-2-carboxylic acid methyl ester are dissolved in 50 ml. of thionyl chloride and boiled to reflux for 16 hours. The mixture is then evaporated to dryness in vacuo and the remaining bright-yellow oil is brought to crystallization with petroleum ether. There is obtained 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.

Quelle