Reaktion #562716

Reaktionsgleichung

Dess-Martin reagent

3-methoxy-3-methyl-1-butanol

Hydroxyamine hydrochloride

3-methoxy-3-methylbutanal

→

N-hydroxy-3-methoxy-3-methylbutan-1-imine

Ausbeute 38.2%

Lösungsmittel

chloroform

Chloroform

pyridine

Ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe organic layer was washed with an aqueous solution of 20 wt. % sodium thiosulfate
2. 2
   TrocknenThe organic layer was dried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
4. 4
   Sonstigeobtaining a crude product
5. 5
   Sonstigeobtained crude product (30 ml) under ice cooling
6. 6
   workup.STIRRINGstirred at room temperature overnight under nitrogen atmosphere
7. 7
   Waschenthe organic layer was washed with water, 1M-hydrochloric acid aqueous solution and saturated brine
8. 8
   TrocknenThe organic layer was dried over magnesium sulfate
9. 9
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
10. 10
    SonstigeThe residue was purified by column chromatography (KP-Sil, Biotage, ethyl acetate/n-hexane=10 to 50%)

Vorschrift

Dess-Martin reagent (15.0 g) was added to a chloroform solution (35 ml) of 3-methoxy-3-methyl-1-butanol (3.3 g) under ice cooling and stirred at room temperature for 5 hours. Chloroform was added to the reaction mixture and the organic layer was washed with an aqueous solution of 20 wt. % sodium thiosulfate, a saturated aqueous solution of sodium hydrogencarbonate and saturated brine. The organic layer was dried over magnesium sulfate and the solvent was distilled off under reduced pressure, thereby obtaining a crude product containing 3-methoxy-3-methylbutanal. Hydroxyamine hydrochloride (3.5 g) was added to a pyridine solution of the obtained crude product (30 ml) under ice cooling and stirred at room temperature overnight under nitrogen atmosphere. Ethyl acetate was added to the reaction mixture and the organic layer was washed with water, 1M-hydrochloric acid aqueous solution and saturated brine. The organic layer was dried over magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (KP-Sil, Biotage, ethyl acetate/n-hexane=10 to 50%), thereby obtaining (N-hydroxy-3-methoxy-3-methylbutan-1-imine (1.4 g) as a colorless oily substance.

Quelle