Reaktion #56210

Reaktionsgleichung

α-cyano-4-fluoro-3-phenoxybenzyl alcohol

2-(2-benzothienyl)-3-methylbutanoic acid

N,N'-dicyclohexylcarbodiimide

→

α-cyano-4-fluoro-3-phenoxybenzyl 2-(2-benzothienyl)-3-methylbutanoate

Lösungsmittel

methylene chloride

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Extraktionextracted with water
3. 3
   ExtraktionThe aqueous phase is extracted with ether
4. 4
   WaschenThe combined organic phases are washed with saturated aqueous sodiun bicarbonate, water and saturated aqueous sodium chloride
5. 5
   Trocknendried over calcium sulfate and solvent
6. 6
   Sonstigeevaporated

Vorschrift

To a stirred solution of α-cyano-4-fluoro-3-phenoxybenzyl alcohol (437 mg, 1.8 mmol), 2-(2-benzothienyl)-3-methylbutanoic acid (2.0 mmol) and 4-dimethylaminopyridine (0.65 mmol) in 20 ml of methylene chloride and 2 ml of dimethylformamide is added N,N'-dicyclohexylcarbodiimide (2.0 mmol). The reaction mixture is stirred, under nitrogen, for two hours and then filtered and extracted with water. The aqueous phase is extracted with ether. The combined organic phases are washed with saturated aqueous sodiun bicarbonate, water and saturated aqueous sodium chloride, dried over calcium sulfate and solvent evaporated to give α-cyano-4-fluoro-3-phenoxybenzyl 2-(2-benzothienyl)-3-methylbutanoate.

Quelle