Reaktion #56205

Reaktionsgleichung

2-(3-benzothienyl)-3-methylbutanoic acid

mesylate

α-cyano-3-phenoxybenzyl alcohol

ethyl acetate hexane

→

α-cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate

Lösungsmittel

THF DMF

THF DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture stirred for about 48 hours

Vorschrift

A mixture of 2-(3-benzothienyl)-3-methylbutanoic acid (3.4 mmol) and KCHO3 (3.4 mmol) on 15 ml THF/DMF (1:1) is stirred for about 15 minutes. The mesylate of α-cyano-3-phenoxybenzyl alcohol (3.4 mmol) in 5 ml THF/DMF is added and the reaction mixture stirred for about 48 hours. The reaction is worked up as in Example 2, developing with 10% ethyl acetate/hexane to yield α-cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate, colorless thick liquid.

Quelle