Reaktion #56202

Reaktionsgleichung

water

5-benzoyl-indan-2-carboxylic acid chloride

monoethanolamine

thionyl chloride

→

N-(2'-hydroxyethyl) 5-benzoyl-indan-2-carboxamide

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis placed in a 250 cm3 reaction vessel
2. 2
   Sonstigeequipped with a stirrer
3. 3
   workup.ADDITIONis slowly added
4. 4
   workup.ADDITIONpoured into iced,
5. 5
   SonstigeA whitish oil separates and finally crystallizes
6. 6
   SonstigeUpon recrystallization from acetone
7. 7
   Sonstigea solid which melts at 106°-107° C. (capillary tube) is obtained

Vorschrift

6.2 g (0.084 mole+20%) of monoethanolamine dissolved in 30 cm3 of dioxane is placed in a 250 cm3 reaction vessel equipped with a stirrer, a cooler, a dropping funnel and a thermometer. At a temperature of between 15° and 20° C., a solution of 12.2 g (0.042 mole) of 5-benzoyl-indan-2-carboxylic acid chloride (prepared in conventional manner by reacting thionyl chloride with the corresponding acid) in 30 cm3 of dioxane is slowly added. The reaction mixture is stirred for one hour at ambient temperature and then poured into iced, acidified water. A whitish oil separates and finally crystallizes. Upon recrystallization from acetone, a solid which melts at 106°-107° C. (capillary tube) is obtained.

Quelle