Reaktion #56188

Reaktionsgleichung

tetrahydrofuran

hydrochloric acid

borane

tetrahydrofuran

tetrahydrofuran

2-benzyl-5-phenyl-1,2,3,4-tetrahydropyrido[4,3-b]indole

→

trans-2-benzyl-2,3,4,4a,5,9b-hexahydro-5-phenyl-1H-pyrido[4,3-b]indole Hydrochloride

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefitted with magnetic stirrer
2. 2
   workup.ADDITIONthermometer, condenser and addition funnel
3. 3
   Temperaturmaintained under a nitrogen atmosphere
4. 4
   workup.ADDITIONwas added a solution of 23.9 g
5. 5
   workup.ADDITIONThe addition
6. 6
   Temperaturto maintain the reaction temperature below 9° C
7. 7
   workup.ADDITIONWhen the addition
8. 8
   Temperaturwas heated
9. 9
   Temperaturto reflux
10. 10
    Temperaturmaintained at this temperature for one hour
11. 11
    SonstigeThe solvent was then evaporated in vacuo
12. 12
    Sonstigeto afford a white solid mass which
13. 13
    TemperaturThe resulting suspension was heated
14. 14
    Temperaturat reflux for one hour
15. 15
    Temperaturcooled
16. 16
    SonstigeEvaporation of tetrahydrofuran and part of the acetic acid
17. 17
    Sonstigeresulted in precipitation of a white solid which
18. 18
    Sonstigewas separated by filtration
19. 19
    Waschenwashed with water
20. 20
    Filtrationfiltered
21. 21
    Waschenwashed with ethyl ether and air
22. 22
    Sonstigedried
23. 23
    Sonstigeto afford 16.7 g

Vorschrift

To a solution of 0.140 moles of borane in 150 ml. of tetrahydrofuran stirred at 0° C. in a three-necked round bottom flask fitted with magnetic stirrer, thermometer, condenser and addition funnel, and maintained under a nitrogen atmosphere, was added a solution of 23.9 g. (0.071 mole) of 2-benzyl-5-phenyl-1,2,3,4-tetrahydropyrido[4,3-b]indole in 460 ml. of dry tetrahydrofuran. The addition was carried out at such a rate as to maintain the reaction temperature below 9° C. When the addition was completed the resulting mixture was heated to reflux and maintained at this temperature for one hour. The solvent was then evaporated in vacuo to afford a white solid mass which was suspended in 40 ml. of dry tetrahydrofuran and heated, slowly at first, with 180 ml. of a 1:1 by volume mixture of acetic acid and 5 N hydrochloric acid. The resulting suspension was heated at reflux for one hour, then cooled. Evaporation of tetrahydrofuran and part of the acetic acid resulted in precipitation of a white solid which was separated by filtration and washed with water. The solid was resuspended in tetrahydrofuran, filtered, washed with ethyl ether and air dried to afford 16.7 g. (63%) of the desired trans-isomer. M.P. 256°-260° C.

Quelle