Reaktion #561160

Reaktionsgleichung

Intermediate 4

2-(cis-2,6-dimethyl-morpholin-4-yl)-5-(2,6-dimethyl-pyridin-4-yl)-thiazole-4-carbonitrile

ammonia

MeOH

hydrogen

→

Intermediate 5

[2-(cis-2,6-dimethyl-morpholin-4-yl)-5-(2,6-dimethyl-pyridin-4-yl)-thiazol-4-yl]-methylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewere absorbed
2. 2
   SonstigeThe catalyst was removed by filtration over diatomaceous earth
3. 3
   SonstigeThe solvent was evaporated

Vorschrift

Intermediate 4 (18.5 g, 56.33 mmol) was added to a suspension of Raney Nickel (2 g) in a 7 N ammonia solution in MeOH (250 mL). The reaction mixture was stirred at 14° C. under hydrogen atmosphere until 2 equivalents of hydrogen were absorbed. The catalyst was removed by filtration over diatomaceous earth. The solvent was evaporated, yielding Intermediate 5 quantitatively. Intermediate 5 was used without further purification.

Quelle