Reaktion #5611

Reaktionsgleichung

5-benzyloxy-2-vinyl-4-pyridone

dimethylamine

→

5-benzyloxy-2-[2-(N,N-dimethylamino)ethyl]-4-pyridone

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe resulting mixture was cooled
2. 2
   Einengenconcentrated under reduced pressure to dryness
3. 3
   SonstigeThe residue was triturated with a mixture of ethyl acetate and diisopropyl ether

Vorschrift

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (3.12 g), 50% aqueous solution of dimethylamine (15 ml) and ethanol (35 ml) was heated at 100° C. in a sealed tube for 8 hours. The resulting mixture was cooled and concentrated under reduced pressure to dryness. The residue was triturated with a mixture of ethyl acetate and diisopropyl ether to give 5-benzyloxy-2-[2-(N,N-dimethylamino)ethyl]-4-pyridone (3.45 g) as a powder.

Quelle