Reaktion #5610

Reaktionsgleichung

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Lösungsmittel

tetrahydrofuran

diisopropyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturrefluxed for an hour
3. 3
   TemperaturThe mixture was cooled
4. 4
   Filtrationthe resulting precipitate was collected by filtration
5. 5
   Waschenwashed with diisopropyl ether
6. 6
   Sonstigeair-dried at ambient temperature

Vorschrift

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

Quelle