Reaktion #5608

Reaktionsgleichung

2-chloromethyl-5-benzyloxy-4-pyridone

tetrahydrofuran

dimethylamine hydrochloride

sodium hydroxide

→

5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

Ausbeute 96.7%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated under reduced pressure to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol
3. 3
   Filtrationthe insoluble material was filtered off
4. 4
   SonstigeThe filtrate was evaporated in vacuo

Vorschrift

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

Quelle