Reaktion #5605

Reaktionsgleichung

ethyl 1-pyrrolidineacetate

sodium hydride

2-(N,N-dimethylamino)ethanol

→

2-(N,N-dimethylamino)-ethyl 1-pyrrolidineacetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was purged with nitrogen gas
2. 2
   Temperaturheated gradually
3. 3
   Sonstigewhile collecting the ethanol by-product in a Dean-Stark trap
4. 4
   SonstigeThe liquid reaction product
5. 5
   workup.DISTILLATIONwas distilled at 85° C. at a pressure of 100 μmHg

Vorschrift

To a mixture of 80 g (0.51 mol) of ethyl 1-pyrrolidineacetate and 0.5 g of sodium hydride (in the form of a 60% by weight suspension in mineral oil) was added 48 g (0.54 mol) of 2-(N,N-dimethylamino)ethanol. The mixture was purged with nitrogen gas, heated gradually and then maintained at about 150° C. while collecting the ethanol by-product in a Dean-Stark trap. The liquid reaction product was distilled at 85° C. at a pressure of 100 μmHg to provide 2-(N,N-dimethylamino)-ethyl 1-pyrrolidineacetate. The structure of the product was confirmed by nuclear magnetic resonance and infrared spectral analysis.

Quelle