Reaktion #56038

Reaktionsgleichung

5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

selenium dioxide

→

5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent is distilled off in vacuo
2. 2
   Sonstigethe oily residue crystallized with diethyl ether

Vorschrift

27 g of 5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 12.2 g selenium dioxide (0.11 mol) are refluxed together in diethyleneglycoldimethyl ether with stirring for 1.5 hours. The solvent is distilled off in vacuo and the oily residue crystallized with diethyl ether. Yield 19 g (66%); m.p. 62°-64° C. (ether).

Quelle