Reaktion #56023

Reaktionsgleichung

2,3-dihydro-3oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile

iodomethane

N,N-dimethylformamide

→

2,3-dihydro-2,5-dimethyl-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated at 100° for 2 hours
2. 2
   FiltrationThe precipitate which forms is filtered out
3. 3
   Sonstigedried in vacuo
4. 4
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 10 parts of 2,3-dihydro-3oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile, 45 parts of iodomethane, and 95 parts of N,N-dimethylformamide is heated at 100° for 2 hours, then diluted with 100 parts of water. The precipitate which forms is filtered out, dried in vacuo, and recrystallized from ethanol to give 2,3-dihydro-2,5-dimethyl-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile melting at approximately 236°-237°.

Quelle