Reaktion #56010

Reaktionsgleichung

malonic acid

diethanol amine

benzaldehyde

→

Bis-(hydroxyethyl)amino benzyl malonic acid

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a stirrer
2. 2
   Temperaturreflux condenser
3. 3
   Sonstigethe reaction commenced
4. 4
   TemperaturAfter refluxing the reaction mixture for 1 hour
5. 5
   Sonstigethe methanol was removed from the reaction mixture
6. 6
   Temperaturheating to a temperature of about 50° C
7. 7
   Sonstigethen was triturated in acetone
8. 8
   Sonstigethe resulting acid isolated by filtration

Vorschrift

Bis-(hydroxyethyl)amino benzyl malonic acid was prepared conventionally in a flask equipped with a stirrer and reflux condenser by first charging 0.1 mol of malonic acid, 0.1 mol of diethanol amine and 100 cc methanol. The contents were warmed to a temperature of about 20° C. and then 0.1 mol benzaldehyde were added to the flask and the reaction commenced. After refluxing the reaction mixture for 1 hour, the methanol was removed from the reaction mixture by coupling the flask to a vacuum source and heating to a temperature of about 50° C. The residue remaining in the flask then was triturated in acetone and the resulting acid isolated by filtration.

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