Reaktion #55996

Reaktionsgleichung

N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

potassium hydroxide

→

N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by evaporation
2. 2
   Extraktionthe residue extracted with ethyl acetate
3. 3
   SonstigeChromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent

Vorschrift

A solution of N-(4-acetylamino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide (e9) (1.4 g) in ethanol (20 ml) was refluxed for 1 hour with an aqueous (4 ml) solution of potassium hydroxide (0.6 g). The solvent was removed by evaporation and the residue extracted with ethyl acetate. Chromatography of the solution (on alumina with 5% water, in chloroform) followed by evaporation of the solvent yielded N-(4-amino-5-chloro-2-methoxyphenyl)-4-benzylpiperazine-1-carboxamide (e10).

Quelle