Reaktion #5592

Reaktionsgleichung

triethylamine

norpinylamine

ethyl ether

acryloyl chloride

ethyl ether

→

title product

N-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe light tan solid was filtered
2. 2
   Waschenwashed well with ethyl ether
3. 3
   SonstigeThe solvent and triethylamine were removed

Vorschrift

Following the procedure of Example 3, a solution of acryloyl chloride (4.05 ml, 0.05 mole) in ethyl ether (50 ml) was added dropwise to a cold 5° C. mixture of triethylamine (15.3 ml, 0.11 mole) and norpinylamine (6.96; g, 0.05 mole) in ethyl ether (400 ml). The reaction was allowed to warm to room temperature and stirred for 72 hours. The light tan solid was filtered and washed well with ethyl ether. The solvent and triethylamine were removed, leaving the title product as an oily solid. The structure was confirmed by NMR.

Quelle