Reaktion #55917

Reaktionsgleichung

2-Methylallyl chloride

4-bromoanisole

sulphuric acid

→

4-bromo-2-(2-chloro-1,1-dimethylethyl)anisole

Lösungsmittel

Ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITthe mixture was then kept for 24 hours at room temperature
2. 2
   Waschenthe resulting solution washed with water, aqueous sodium bicarbonate solution and water again
3. 3
   TrocknenAfter drying with sodium sulphate
4. 4
   Sonstigeevaporating off the solvent the brown oil which
5. 5
   workup.DISTILLATIONremained was distilled

Vorschrift

2-Methylallyl chloride (108 parts) was added dropwise to a mixture of 4-bromoanisole (240 parts) and a concentrated sulphuric acid (20 parts) over a period of 2 hours at a temperature of 25°-35° C. Stirring was continued for 5 hours and the mixture was then kept for 24 hours at room temperature. Ether (400 parts) was then added and the resulting solution washed with water, aqueous sodium bicarbonate solution and water again. After drying with sodium sulphate and evaporating off the solvent the brown oil which remained was distilled yielding 4-bromo-2-(2-chloro-1,1-dimethylethyl)anisole (118 parts), boiling point 106°-120°/0.4 mm Hg. Recrystallisation from petroleum ether (b.p. 80°-100° C.) gave the pure product (98 parts), melting point 86°-88° C.

Quelle