Reaktion #558948

ord-1a782fd57e0b4912a0d6ec400fbd335c

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCC(COc2cccc([N+](=O)[O-])c2C#N)C1
tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate
CC(C)(C)OC=O
H-Boc
→
CC(C)(C)OC(=O)N1CCCC(COc2cccc(N)c2C#N)C1
tert-butyl 3-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate
Ausbeute 100.0%

Edukte

CC(C)(C)OC(=O)N1CCCC(COc2cccc([N+](=O)[O-])c2C#N)C1
tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate
CC(C)(C)OC=O
H-Boc

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared as in example 254b from tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate (Example 262e) in 100% yield as an oil. MS 232 [M+H-Boc]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08633186B2uspto-grants-2014_01