Reaktion #558648

Reaktionsgleichung

2-amino-4,5-dimethylthiophene-3-carbonitrile

benzoylisothiocyanate

→

N-(3-Cyano-4,5-dimethylthiophen-2-ylcarbamothioyl)benzamide

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitation
2. 2
   Filtrationwas collected by filtration
3. 3
   Waschenwashed with EtOAc/Hexanes (1:4)
4. 4
   Sonstigedried under vacuum overnight

Vorschrift

To a solution of 2-amino-4,5-dimethylthiophene-3-carbonitrile (1.52 g, 10.0 mmol) in 1,4-dioxane (20 mL) was added benzoylisothiocyanate (1.63 g, 10.0 mmol). The reaction mixture was then stirred at room temperature under nitrogen overnight. The precipitation was collected by filtration, washed with EtOAc/Hexanes (1:4), and dried under vacuum overnight to give N-(3-Cyano-4,5-dimethylthiophen-2-ylcarbamothioyl)benzamide as a white solid. 1H NMR (400 MHz, CDCl3) δ 2.23 (s, 3H), 2.31 (s, 3H), 7.58-7.54 (m, 2H), 7.68-7.66 (m, 1H), 7.94 (d, J=7.2 Hz, 2H), 9.13 (bs, 1H). MS 316 (MH+).

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