Reaktion #558636

ord-483e8023e88646b98d3928fe1c10eef0

Reaktionsgleichung

Cc1cc(O)cc(C)c1Br
4-Bromo-3,5-dimethylphenol
CS(=O)(=O)O[C@H]1CCN(S(C)(=O)=O)C1
Methanesulfonic acid (S)-1-methanesulfonyl-pyrrolidin-3-yl ester
→
Cc1cc(O[C@@H]2CCN(S(C)(=O)=O)C2)cc(C)c1Br
title compound
Cc1cc(O[C@@H]2CCN(S(C)(=O)=O)C2)cc(C)c1Br
(R)-3-(4-Bromo-3,5-dimethyl-phenoxy)-1-methanesulfonyl-pyrrolidine

Edukte

—
Intermediate 36
Cc1cc(O)cc(C)c1Br
4-Bromo-3,5-dimethylphenol
CS(=O)(=O)O[C@H]1CCN(S(C)(=O)=O)C1
Methanesulfonic acid (S)-1-methanesulfonyl-pyrrolidin-3-yl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared in analogy to Intermediate 36 from 4-Bromo-3,5-dimethylphenol (626 mg, 3.08 mmol) and Methanesulfonic acid (S)-1-methanesulfonyl-pyrrolidin-3-yl ester (300 mg, 1.23 mmol). (Yield: 350 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08633182B2uspto-grants-2014_01