Reaktion #558625

Reaktionsgleichung

3-Methyl-1,3-butanediol

pyridine

4-toluenesulfonyl chloride

→

title compound

Toluene-4-sulfonic acid 3-hydroxy-3-methyl-butyl ester

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthen washed with 1M aqueous hydrochloric acid
2. 2
   Sonstigedried
3. 3
   Sonstigethe solvent removed under vacuum
4. 4
   SonstigeThe residue is purified by flash chromatography (0-30% ethyl acetate in cyclohexane)

Vorschrift

3-Methyl-1,3-butanediol (1.5 mL, 14.06 mmol) is suspended in dry dichloromethane (5 mL) and pyridine (1.24 mL, 15.46 mmol) is added followed by 4-toluenesulfonyl chloride (2.68 g, 14.06 mmol). The mixture is stirred overnight then washed with 1M aqueous hydrochloric acid, dried and the solvent removed under vacuum. The residue is purified by flash chromatography (0-30% ethyl acetate in cyclohexane) to give the title compound. (Yield 970 mg).

Quelle