Reaktion #557818

Reaktionsgleichung

toluene

hexanenitrile

hydroxylamine hydrochloride

sodium bicarbonate

→

title compound

N-hydroxy-heptanimidamide

Lösungsmittel

isopropyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred at 80° C. to 85° C. for 3-4 h
2. 2
   SonstigeAfter completion of the reaction
3. 3
   Temperaturthe reaction mixture was cooled to 25° C. to 30° C.
4. 4
   Filtrationfiltered
5. 5
   Waschenwashed with 2 mL of isopropyl alcohol
6. 6
   SonstigeThe filtrate was collected
7. 7
   workup.DISTILLATIONdistilled out completely
8. 8
   Sonstigeto obtain a crude residue, which

Vorschrift

To a solution of 0.93 g (13.4 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.66 g (19.78 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (8.9 mmol) of hexanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After completion of the reaction, the reaction mixture was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue, which was chased with 5 mL of toluene, to yield the title compound.

Quelle