Reaktion #557815

Reaktionsgleichung

hexanenitrile

toluene

hydroxylamine hydrochloride

sodium bicarbonate

→

title compound

N-hydroxy hexanimidamide

Lösungsmittel

isopropyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred at 80° C. to 85° C. for 3-4 h
2. 2
   SonstigeAfter the reaction period
3. 3
   Sonstigethe reaction mixtures
4. 4
   Temperaturwas cooled to 25° C. to 30° C.
5. 5
   Filtrationfiltered
6. 6
   Waschenwashed with 2 mL of isopropyl alcohol
7. 7
   SonstigeThe filtrate was collected
8. 8
   workup.DISTILLATIONdistilled out completely
9. 9
   Sonstigeto obtain a crude residue

Vorschrift

To a solution of 0.107 g (15.4 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.90 g (22.64 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (10.2 mmol) of hexanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After the reaction period, the reaction mixtures was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue with chased with 5 mL of toluene, to yield the title compound.

Quelle