Reaktion #55771

Reaktionsgleichung

2-mercaptoimidazole

3-aminopropanol

hydrobromic acid

→

2-(3-aminopropylthio)imidazole dihydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 25 hours
2. 2
   SonstigeThe reaction mixture was evaporated to dryness
3. 3
   Sonstigethe oily residual solid recrystallised twice from ethanol/ether

Vorschrift

A solution of 2-mercaptoimidazole (2 g.) and 3-aminopropanol (1.14 ml.) in hydrobromic acid (48%, 25 ml.) was heated under reflux for 25 hours. The reaction mixture was evaporated to dryness and the oily residual solid recrystallised twice from ethanol/ether to give 2-(3-aminopropylthio)imidazole dihydrobromide (3.55 g.), m.p. 160°-162°.

Quelle