Reaktion #5577

Reaktionsgleichung

5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride

→

desired product

Ausbeute 99.7%

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

Ausbeute 99.7%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed with 3N sodium hydroxide (50 ml)
2. 2
   Extraktionthe aqueous layer was extracted with chloroform
3. 3
   Trocknenthe combined chloroform layer was dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThen, the solvent was distilled off

Vorschrift

After a suspension of 5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Quelle