Reaktion #55768

Reaktionsgleichung

sodium nitrite

ethyl isobutyrylacetate

→

ethyl 2-oximino-4-methyl-3-oxopentanoate

Ausbeute 94.4%

Lösungsmittel

water

acetic acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat room temperature for 3 hours
2. 2
   Extraktionthe mixture extracted with ether
3. 3
   WaschenThe extracts were washed with water, saturated sodium bicarbonate solution and water
4. 4
   TrocknenAfter drying (CaSO4)
5. 5
   Sonstigethe solution was evaporated

Vorschrift

A solution of sodium nitrite (43.8 g.) in water (92 ml.) was added dropwise, with stirring, to a solution of ethyl isobutyrylacetate (100.3 g.) in acetic acid (80 ml.) at 0°. After stirring at 0° for 30 minutes then at room temperature for 3 hours, water (100 ml.) was added and the mixture extracted with ether. The extracts were washed with water, saturated sodium bicarbonate solution and water. After drying (CaSO4), the solution was evaporated to give ethyl 2-oximino-4-methyl-3-oxopentanoate (112 g.) as a crude oil.

Quelle