Reaktion #55767

Reaktionsgleichung

Sulphuryl chloride

ethyl 3-oxopentanoate

→

ethyl 2-chloro-3-oxopentanoate

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONaddition the mixture
2. 2
   Temperaturheated
3. 3
   Temperaturunder reflux for 0.5 hour
4. 4
   Temperaturcooled
5. 5
   WaschenAfter washing with water, sodium bicarbonate and water
6. 6
   Trocknenthe solution was dried (sodium sulphate)
7. 7
   Einengenconcentrated

Vorschrift

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

Quelle