Reaktion #55764

Reaktionsgleichung

homocysteamine hydrochloride

4-hydroxymethyl-5-methylimidazole hydrochloride

hydrobromic acid

→

4-methyl-5-[(3-aminopropyl)thiomethyl]-imidazole dihydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for one hour
2. 2
   EinengenConcentration under reduced pressure
3. 3
   Sonstigefollowed by recrystallisation from methanol-isopropyl alcohol

Vorschrift

A solution of homocysteamine hydrochloride (22.0 g.) and 4-hydroxymethyl-5-methylimidazole hydrochloride (25.6 g.) in aqueous hydrobromic acid (500 ml.) was heated under reflux for one hour. Concentration under reduced pressure, followed by recrystallisation from methanol-isopropyl alcohol afforded 4-methyl-5-[(3-aminopropyl)thiomethyl]-imidazole dihydrobromide (24.5 g.), m.p. 200.5°-202.5°.

Quelle