Reaktion #55743

Reaktionsgleichung

hydrochloric acid

5-chloro-2-methoxy-benzoyl chloride

hydrochloride

NaOH

→

5-chloro-2-methoxy-benzoic acid

Lösungsmittel

water

acetone

water

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe product was recrystallized from methanol

Vorschrift

2.5 g of hydrochloride were dissolved in 25 ml of acetone and 0.8 g of NaOH in 20 ml of water. To this solution, there were added 2 g of 5-chloro-2-methoxy-benzoyl chloride in 20 ml of acetone and the whole was stirred for 1 hour. Then, water and dilute hydrochloric acid were added and the product was recrystallized from methanol. The 4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-5-chloro-2-methoxy-benzoic acid so obtained was found to melt at 171°-173° C.

Quelle