Reaktion #55741

Reaktionsgleichung

2-ethoxy-5-chloro-benzoylchloride

4-(2-aminoethyl)-benzoic acid hydrochloride

→

benzoic acid

Lösungsmittel

acetone

water

acetone

sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStirring
2. 2
   Filtrationfiltered
3. 3
   FiltrationAfter filtration with suction
4. 4
   Sonstigethe product was recrystallized from ethanol

Vorschrift

10 g of 4-(2-aminoethyl)-benzoic acid hydrochloride were dissolved in 60 ml of 2 N-sodium hydroxide solution and, after addition of 75 ml of acetone, a solution of 11 g of 2-ethoxy-5-chloro-benzoylchloride in 20 ml of acetone was added dropwise, while stirring. Stirring was continued for 2 hours, the mixture was diluted with water, filtered and acidified with dilute hydrochloric acid. After filtration with suction, the product was recrystallized from ethanol. The 4-(2-<2-ethoxy-5-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 180° C.

Quelle