Reaktion #55721

Reaktionsgleichung

9-(1-Hydroxy-2-propyl)-6-chloropurine

hydroiodic acid

→

9-(1-HYDROXYL-2-PROPYL)-6-IODOPURINE

Lösungsmittel

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Sonstigeneutralized with anhydrous sodium acetate at 5°
3. 3
   Waschenwashed with a little cold water (3 times)
4. 4
   SonstigeRecrystallization from ethanol/H2O
5. 5
   Sonstigegave colorless crystals

Vorschrift

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194° uv λmax 276 nm (H2O, pH 5.5).

Quelle