Reaktion #5570

Reaktionsgleichung

5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine

hydrochloric acid

→

desired product

5-[2-(amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine.dihydrochloride

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThen, the solvent was distilled off

Vorschrift

To a suspension of 5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine (364 mg, 1.08 mmoles) in methanol (3 ml) was added conc. hydrochloric acid (2 ml) and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off to obtain 340 mg of the desired product (quantitative, brown solid).

Quelle