Reaktion #55650

Reaktionsgleichung

3-[2-(4-methoxyphenyl)ethyl]-glutaric acid

ethanethiol

→

title compound

Ausbeute 88.0%

3-[2-(4-Hydroxyphenyl)ethyl]glutaric acid

Ausbeute 88.0%

Lösungsmittel

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeresults
2. 2
   Temperaturthe mixture is heated
3. 3
   workup.STIRRINGwith stirring in a bath at 165° C. for 6.0 hours
4. 4
   SonstigeThe mixture is then evaporated to dryness in vacuo
5. 5
   workup.DISSOLUTIONthe resulting residue is dissolved in water (50 ml)
6. 6
   Extraktionextracted with ether (two 50 ml portions)
7. 7
   Extraktionthe ether extract
8. 8
   Extraktionextracted with ethyl acetate
9. 9
   WaschenThe ethyl acetate solution is washed with brine
10. 10
    Trocknendried with anhydrous magnesium sulfate
11. 11
    Sonstigeevaporated to a residue
12. 12
    SonstigeCrystallization of this from chloroform-hexane

Vorschrift

To a suspension of 57% sodium hydride-paraffin (2.2 g) in dry dimethylformamide (70 ml) in an atmosphere of nitrogen is slowly added ethanethiol (4.0 ml). The mixture is stirred at room temperature until a clear solution results. To this solution is added a solution of 3-[2-(4-methoxyphenyl)ethyl]-glutaric acid (1.2 g) in dry dimethylformamide (10 ml) and the mixture is heated with stirring in a bath at 165° C. for 6.0 hours. The mixture is then evaporated to dryness in vacuo and the resulting residue is dissolved in water (50 ml), extracted with ether (two 50 ml portions) and the ether extract is discarded. The aqueous solution is acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The ethyl acetate solution is washed with brine, dried with anhydrous magnesium sulfate, and evaporated to a residue. Crystallization of this from chloroform-hexane affords 1.0 g of the title compound, melting point 142°-144° C.

Quelle