Reaktion #55616

Reaktionsgleichung

N-chloroacetyl-2,6-dimethylaniline

3-methyl-5-chloromethylisoxazole

sodium hydride

→

pure product

Ausbeute 30.0%

2-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide

Ausbeute 30.0%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter workup, the solid product was purified by column and high-pressure liquid chromatography

Vorschrift

A mixture of 4.54 g N-chloroacetyl-2,6-dimethylaniline and 3 g 3-methyl-5-chloromethylisoxazole (prepared as in Example 8 above) in 100 ml dry dimethylformamide was treated with 1.33 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield 2.0 g pure product, m.p. 78°-82° C. This product is shown as Compound 1 in Table I. C15H17ClN2O2 : calc., %C 61.54, %H 5.81, %N 9.57; found, %C, 63.37, %H 6.16, %N 9.65.

Quelle