Reaktion #55615

Reaktionsgleichung

N-chloroacetyl-2,6-dimethylaniline

3-bromomethylisoxazole

sodium hydride

→

2-chloro-N-(isoxazol-3-yl)methyl-N-(2,6-dimethylphenyl)acetamide

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter workup, the solid product was purified by column and high-pressure liquid chromatography
2. 2
   Sonstigeto yield a pure product, m.p. 78°-81° C

Vorschrift

A mixture of 6.1 g N-chloroacetyl-2,6-dimethylaniline and 5 g 3-bromomethylisoxazole (prepared as in Example 6 above) in 200 ml dry dimethylformamide was treated with 1.5 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield a pure product, m.p. 78°-81° C. This product is shown as Compound 2 in Table I. C14H15ClN2O2 : calc., %C 60.32, %H 5.39, %N 10.05; found, %C 60.72, %H 5.71, %N 8.85.

Quelle