Reaktion #55595

Reaktionsgleichung

m-Fluorobenzonitrile

sulfuric acid

potassium nitrate

→

3-cyano-4-nitrofluorobenzene

Ausbeute 86.5%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with chloroform (5×250 ml.)
2. 2
   Sonstigedried
3. 3
   Sonstigethe solvent removed
4. 4
   ExtraktionThe residue is extracted with pentane
5. 5
   Sonstigedried

Vorschrift

m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3°-6° C., then allowed to warm to 25° C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5×250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102°-104° C.

Quelle