Reaktion #55591

Reaktionsgleichung

Cyclobutane carbinol

tosyl chloride

HCl

→

title compound

Ausbeute 105.8%

(p-Toluenesulfonyloxy) (cyclobutyl) methane

Ausbeute 105.8%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe layers were separated
2. 2
   Extraktionthe aqueous layer extracted with ether-ethyl acetate
3. 3
   WaschenThe combined extracts were washed with 10% aqueous sodium bicarbonate (NaHCO3)
4. 4
   Trocknendried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated in vacuo

Vorschrift

A solution of 24.4 g of Cyclobutane carbinol (prepared in Example 42A) in 570 ml of dry pyridine was stirred under argon at -10° C. and 81.0 g of tosyl chloride added in small portions. The reaction mixture was stirred at -10° C. to -0° C. for 4.5 hr, then poured into 1 liter of chilled 6 N HCl. The layers were separated and the aqueous layer extracted with ether-ethyl acetate. The combined extracts were washed with 10% aqueous sodium bicarbonate (NaHCO3), dried (MgSO4), filtered and evaporated in vacuo to yield 72.0 g of the title compound having the following physical characteristics:

Quelle