Reaktion #55566

Reaktionsgleichung

9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester

NaOH

→

9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid

Ausbeute 91.5%

Lösungsmittel

water

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with diethyl ether (10 ml)
2. 2
   Extraktionextracted with diethyl ether (3×15 ml)
3. 3
   WaschenThe ethereal solution is washed with water to neutrality
4. 4
   Trocknendried over sodium sulphate
5. 5
   Sonstigethe solvent evaporated in vacuo

Vorschrift

The solution of 0.5 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester, 0.170 g of NaOH in water (1.5 ml), methanol (4.5 ml) is left for two hours at room temperature under nitrogen, then diluted with water (22 ml) and extracted with diethyl ether (10 ml). The aqueous layer is acidified (congo red) with HCl (5%), then extracted with diethyl ether (3×15 ml). The ethereal solution is washed with water to neutrality, dried over sodium sulphate and the solvent evaporated in vacuo to yield 0.44 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid (oil).

Quelle