Reaktion #555566

Reaktionsgleichung

5-Nitro-2-(pyridin-2-yl)-1H-indole

→

2-(piperidin-2-yl)-1H-indol-5-amine

Ausbeute 110.6%

Lösungsmittel

HCl MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated under vacuum
2. 2
   workup.ADDITIONPtO2 (200 mg) was added to a solution of the residue in MeOH (50 mL)
3. 3
   workup.STIRRINGthe reaction mixture was stirred under hydrogen atmosphere (1 atm) at room temperature for 2 h
4. 4
   FiltrationThe catalyst was filtered through a celite pad
5. 5
   Sonstigethe solvent was evaporated under vacuum

Vorschrift

5-Nitro-2-(pyridin-2-yl)-1H-indole (1.0 g, 4.2 mmol) was added to HCl/MeOH (2 M, 50 mL). The reaction mixture was stirred at room temperature for 1 h and the solvent was evaporated under vacuum. PtO2 (200 mg) was added to a solution of the residue in MeOH (50 mL) and the reaction mixture was stirred under hydrogen atmosphere (1 atm) at room temperature for 2 h. The catalyst was filtered through a celite pad and the solvent was evaporated under vacuum to afford 2-(piperidin-2-yl)-1H-indol-5-amine (1.0 g), which was directly used in the next step.

Quelle