Reaktion #55546

Reaktionsgleichung

ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate

methanol

sodium hydroxide

→

2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetic acid

Ausbeute 77.3%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe reaction mixture was treated in a conventional manner

Vorschrift

A mixture of ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate (syn isomer, 2.8 g.), methanol (23 ml.), tetrahydrofuran (20 ml.) and 1 N aqueous solution of sodium hydroxide (22.17 ml.) was stirred at 30° C. for 5 hrs. The reaction mixture was treated in a conventional manner to give 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetic acid (syn isomer, 1.924 g.).

Quelle