Reaktion #55542

Reaktionsgleichung

ethyl 2-(2-aminothiazol-4-yl)-2-allyloxyiminoacetate

sodium hydroxide

tetrahydrofuran

→

2-(2-aminothiazol-4-yl)-2-allyloxyiminoacetic acid

Ausbeute 59.6%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resultant solution was concentrated in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water
3. 3
   Filtrationthe precipitates were collected by filtration
4. 4
   Waschenwashed with water and acetone in turn
5. 5
   Sonstigedried

Vorschrift

A solution of ethyl 2-(2-aminothiazol-4-yl)-2-allyloxyiminoacetate (syn isomer, 3.6 g), 2 N aqueous solution of sodium hydroxide (14.1 ml), tetrahydrofuran (14.1 ml) and methanol (15 ml) as stirred at 40° C. for 1.5 hours. The resultant solution was concentrated in vacuo, and the residue was dissolved in water. After the solution was adjusted to pH 2.8 with 10% hydrochloric acid under ice cooling, the precipitates were collected by filtration, washed with water and acetone in turn and dried to give 2-(2-aminothiazol-4-yl)-2-allyloxyiminoacetic acid (syn isomer, 1.91 g), mp. 187° C. (dec.).

Quelle