Reaktion #55485

ord-66649ce96602436f818ee91f78ecfcf8

Reaktionsgleichung

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
17β-hydroxy-4-androsten-3one
CS(C)=O
dimethyl sulphoxide
→
C[C@]12CC[C@H]3[C@@H]([C@H](O)CC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
7α,17β-dihydroxy-4-androsten-3-one

Edukte

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
17β-hydroxy-4-androsten-3one
CS(C)=O
dimethyl sulphoxide

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
26.5°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.WAITincubated for 8 days

Vorschrift

100 ml of the medium of Example 1 were inoculated with Mucor hiemalis FERM P-3800 and shaken at 26.5° C. for 22 hours. The culture was then treated with 50 mg of 17β-hydroxy-4-androsten-3one in 1 ml of dimethyl sulphoxide and incubated for 8 days. There were obtained from the culture filtrate 4.8 mg of 7α,17β-dihydroxy-4-androsten-3-one of melting point 191°-193° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04220716uspto-grants-1980_09