Reaktion #55469

Reaktionsgleichung

hydrogen chloride

2,6-dichloroaniline

HCl

m-cresol

sodium hydroxide

cyanamide

→

2,6-dichlorophenylguanidine hydrochloride

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated on a steam bath
2. 2
   Temperaturthen heated for 2 hours on a steam bath
3. 3
   TemperaturThe reaction mixture is then cooled
4. 4
   Temperaturcooled
5. 5
   Extraktionextracted with 2 liters of ether
6. 6
   WaschenThe ether layer is washed with 2×1 liter of water
7. 7
   Trocknendried over sodium sulfate
8. 8
   Sonstigeevaporated
9. 9
   SonstigeThe residue is triturated with hexane
10. 10
    Filtrationthe precipitate is filtered off
11. 11
    Waschenwashed with ether
12. 12
    Sonstigedried

Vorschrift

To 51 g (0.315 mole) of 2,6-dichloroaniline is added 0.4 moles of ethereal HCl and 200 ml of m-cresol. The mixture is then stirred and heated on a steam bath to drive off the ether and excess hydrogen chloride. To the resultant mixture is then added 13.3 g (0.315 mole) of cyanamide then heated for 2 hours on a steam bath. The reaction mixture is then cooled, added to 150 ml of conc. sodium hydroxide solution, cooled and extracted with 2 liters of ether. The ether layer is washed with 2×1 liter of water, dried over sodium sulfate, charcoaled and evaporated. The residue is triturated with hexane and the precipitate is filtered off and washed with ether and dried to obtain 2,6-dichlorophenylguanidine hydrochloride.

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