Reaktion #554645

Reaktionsgleichung

5-bromo-2-chloropyrimidine

cyclobutylamine

DIPEA

ACN

→

5-Bromo-N-cyclobutylpyrimidin-2-amine

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water (2×)
2. 2
   Trocknenphase is dried with MgSO4
3. 3
   Filtrationfiltered
4. 4
   Sonstigethe solvent is removed in vacuo

Vorschrift

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamine and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4, filtered and the solvent is removed in vacuo.

Quelle