Reaktion #554643

ord-e2a0d5eb27f54a2c8c9fae9d97057072

Reaktionsgleichung

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF
→
Brc1ccc(OCC2CC2)cc1
1-Bromo-4-cyclopropylmethoxybenzene

Edukte

Oc1ccc(Br)cc1
4-bromophenol
ClCC1CC1
(chloromethyl)cyclopropane
O=C([O-])[O-].[K+].[K+]
K2CO3
CN(C)C=O
DMF

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Temperatur
80°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Extraktionextracted with DCM
  2. 2
    TrocknenThe organic layer is dried with MgSO4
  3. 3
    Filtrationfiltered
  4. 4
    Sonstigethe solvent is removed in vacuo

Vorschrift

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4, filtered and the solvent is removed in vacuo.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08623860B2uspto-grants-2014_01