Reaktion #554641

Reaktionsgleichung

acetic anhydride

1-(4-bromophenyl)propane-2-amine

→

N-(1-(4-Bromophenyl)propan-2-yl)acetamide

Lösungsmittel

AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent is evaporated in vacuo
2. 2
   SonstigeThe layers are separated
3. 3
   Waschenthe organic layer is washed with water
4. 4
   Trocknendried with Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Sonstigethe solvent is removed in vacuo
7. 7
   SonstigeThe crude product is triturated with DIPE

Vorschrift

17.0 mL (179.7 mmol) acetic anhydride are added to a mixture of 24.2 g (113 mmol) 1-(4-bromophenyl)propane-2-amine and 20 mL AcOH and the reaction mixture is stirred at r.t. over night. The solvent is evaporated in vacuo, and the residue partitonated between TBME and a saturated aq. NaHCO3 solution. The layers are separated and the organic layer is washed with water, dried with Na2SO4, filtered and the solvent is removed in vacuo. The crude product is triturated with DIPE.

Quelle