Reaktion #554640

Reaktionsgleichung

4-bromophenylacetone

ammonia

hydrogen

→

1-(4-Bromophenyl)propane-2-amine

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter complete reaction
2. 2
   Filtrationthe mixture is filtrated
3. 3
   WaschenThe residue is washed with MeOH
4. 4
   Sonstigethe solvent of the filtrate is removed in vacuo
5. 5
   SonstigeThe crude product is used without further purification

Vorschrift

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

Quelle